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KMID : 0359719920100010001
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Journal of the Korean Neurological Association
1992 Volume.10 No. 1 p.1 ~ p.7
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Diagnosis of Tuberculous Meningitis by Enzyme-Linked Immunosorbent Assay(ELSA) and Polymerase Chain Reaction(PCR) in CSF
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김원주
김윤중/박수철/이병인/윤경한/조상래/김주덕
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Abstract
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Cerebrospinal fluid from 27 patients with tuberculous meningitis and from appropriate control individuals were assayed for immunoglobulin G activity to tuberculin purified protein derivative (PPD0 and Lipoarabinomannan-B(LAM-B) antigens by an
enzume-linked immunosorbent assy (ELISA), and polvmerase chin reaction (PCR0. A significant difference was found between the tuberculous meningitis group and control. The sensitivity and speciticity of these tests in cerebrospinal fluid was 59.2%
and
93.9% for PPD, 85.2% and 95.9% for LAM-B antigen and 70.3% and 89.7% for PCR method. The ELISA mechod measuring IgG antibody to LAM-B in cerebrospinal fluid and PCR method were both reliable and conplementary each other for early diagnosis of
patient
with tuberculous meningitis.
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KEYWORD
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